sorbitol anhydride monooleate reaction 2


    46 CHAPTER 3 ESTERFICATION OF MALEIC ANHYDRIDE WITH ETHANOL The catalyst plays an important role in many reactions such as alkylation, acylation, cyclization, aldol condensation, Knoevenagel

  • Organic acid anhydride - Wikipedia

    An organic acid anhydride is an acid anhydride that is an organic compound.An acid anhydride is a compound that has two acyl groups bonded to the same oxygen atom. A common type of organic acid anhydride is a carboxylic anhydride, where the parent acid is a carboxylic acid, the formula of the anhydride being (RC(O)) 2 O. Symmetrical acid anhydrides of this type are named by replacing the word ...

  • Sorbitol Production | Air Liquide

    Sorbitol Production is a technology for creating the sugar alcohol sorbitol through the batchwise hydrogenation of aqueous glucose solution. Through this reliable process, Air Liquide Engineering & Construction enables its clients to produce technical, food or pharmaceutical grade sorbitol.

  • Polyoxyethylene sorbitan monooleate | - PubChem

    Water is initially removed from the sorbitol to form a sorbitan (a cyclic sorbitol anhydride). The sorbitan is then partially esterified with a fatty acid, such as oleic or stearic acid, to yield a hexitan ester. Finally, ethylene oxide is chemically added in the presence of a catalyst to yield the polysorbate.

  • sorbitan oleate, 1338-43-8 - The Good Scents Company

    International trading and distribution: ECSA Group offers its customers in these business segments a complete 'one-stop shopping' solution. A hundred years on from its establishment, the Emanuele Centonze Holding SA has developed a solid presence in Switzerland and in Europe.

  • Manufacture of fatty acid esters of sorbitan as surfactants ...

    A method of making fatty acid esters of sorbitan which comprises reacting the fatty acid directly with sorbitol in the presence of a catalyst system which comprises a phosphorus oxyacid, including a reducing phosphorus oxyacid, and an alkali or alkali earth metal strong base in a molar ratio of acid to base of from 0.9:1 to 1.7:1 and at a ...

  • Changzhou ComWin Fine Chemicals Co.,Ltd. is a member of ...

    ComWin Fine Chemicals, founded in 2003, is located in Changzhou City, a beautiful historical and cultural city with a thousand years' history. Its manufacturing facility is situated in Changzhou Hi-Tech Industrial Zone.

  • Succinic anhydride ≥99% (GC) | Sigma-Aldrich

    The molecule of succinic anhydride consists of 3, 4, and 5 triangles and each triangle is a part of three carbon molecules forming a zigzag structure. Application Succinic anhydride was used in the preparation of covalently cross-linked oxidized-alginate/N-succi nyl-chitosan hydrogels, as injectable systems towards tissue engineering.

  • Sorbitan | definition of sorbitan by Medical dictionary

    sorbitan: ( sōr'bi-tan ), Sorbitol or sorbose and related compounds in ester combination with fatty acids and with short oligo (ethylene oxide) side chains and an oleate terminus to form detergents such as polysorbate 80.

  • Sorbitan - Wikipedia

    Synthesis. Sorbitan is produced by the dehydration of sorbitol and is an intermediate in the conversion of sorbitol to isosorbide.The dehydration reaction usually produces sorbitan as a mixture of five- and six-membered cyclic ethers (1,4-anhydrosorbitol, 1,5-anhydrosorbitol and 1,4,3,6-dianhydrosorbitol) with the five-membered 1,4-anhydrosorbitol form being the dominate product.

  • FDA Amends Regulations for Sorbitol Anhydride Esters

    The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of sorbitol anhydride esters, an emulsifier blend of sorbitan monostearate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60) and polyoxyethylene (20) sorbitan monolaurate (polysorbate 20) as an anticorrosive agent in boilers where steam may contact food.

  • Sorbitol side effects and allergic reactions - Ask A Healer

    A few times, when I had the reaction, I doubted myself because I couldn't find a food that I had eaten to explain the symptoms. Then, I started reading labels on my homeopathic pellets and other health supplements. Yep, sorbitol. I avoid it like the plague now. The Main Side Effects or Allergic Reactions I Experienced from Sorbitol Include:

  • USP Excipient Stakeholder Forum, September 29 2016

    Purify the Sorbitol & Sorbitan and fix their reaction proportion; (2) Process route (First polymerize,then esterify) Ethylene oxide react prior with sorbitol and sorbitol anhydride and occupy hydroxyl group site, which aviod the uncontrollable incessant dehydration in the stage of

  • Sorbitol - Wikipedia

    Sorbitol may be synthesised via a glucose reduction reaction in which the converted aldehyde group is converted into a hydroxyl group. The reaction requires NADH and is catalyzed by aldose reductase. Glucose reduction is the first step of the polyol pathway of glucose metabolism, and is implicated in multiple diabetic complications.

  • Intro to Organic Chemistry: Carboxylic Acids; Carboxylic ...

    1. reaction of a carboxylic acid with an amine + heat creates an ammonium salt which will yield an amide + H2O 2. reaction of an anhydride with an amine creates an amide and carboxylic acid byproduct (which then further neutralizes to an ammonium salt in the presence of a second mole of amine ).

  • Component-based biocompatibility and safety evaluation of ...

    In general, polysorbate 80 is synthesized through dehydration of sorbitol, esterification with oleic acid and etherification with ethylene oxide . 1 However, it is possible that the first step of dehydration generates two main products, i.e., 1,4-sorbitan by losing one H 2 O molecule (sorbitol anhydride) and 1,4- or 3,6-isosorbide by losing two ...

  • Sorbitol | C6H14O6 | ChemSpider

    The food industry uses D-sorbitol as an additive in the form of a sweetener, humectant, emulsifier, thickener, or dietary supplement. D-Sorbitol has also been found in cosmetics, paper, and pharmaceuticals. Naturally, D-sorbitol occurs widely in plants via photosynthesis, ranging from algae to higher order fruits of the family Rosaceae.

  • Sorbitol Side Effects: Common, Severe, Long Term - provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

  • Solvent-Free Polymerization of Citric Acid and D-Sorbitol

    anhydride and then react with the alcohol (Scheme 1, top reaction).2 Copolyesters of citric acid and 1,2,6-hexane triol have also been cited as possible candidates for drug delivery.21–23 The reaction of citric acid and D-sorbitol is expected to run without catalysis, forming the citrate sorbitol ester.9 The well-precedented an-


    The term sorbitan describes the anhydride form of sorbitol, whose fatty acids are lipophilic whereas sorbitol body is hydrophilic. This bifunctionality in one molecule provides the basic properties useful in cleaners, detergents, polymer additives, and textile industry as emulsifiers, wetting agents, and viscosity modifiers.


    were prepared by lipase catalyzed controlled esterification reaction between sorbitol and fatty acids. In this study, enzymatic reaction was performed in organic solvent mixtures of pure DMSO and Tert. Butanol in 80:20 ratio in percentage(v/v).The enzymatic synthesis was carried out by the reaction of sorbitol and various fatty acids like oleic,

  • acid anhydrides with ammonia or primary amines - chemguide

    This page looks at the reactions of acid anhydrides with ammonia and with primary amines. These reactions are considered together because their chemistry is so similar. There is also a great similarity between acid anhydrides and acyl chlorides (acid chlorides) as far as these reactions are ...


    It is used for vitamin-C fermentation. It is used as a excipient and intravenous osmotic diuretic in pharmaceutical fields. It is also used in the manufacture of polyethers for polyurethanes and surfactants. The term sorbitan describes the anhydride form of sorbitol, whose fatty acids are lipophilic whereas sorbitol body is hydrophilic.

  • Acid-Catalyzed Dehydration of Sorbitol to 1,4-Sorbitan ...

    Acid-Catalyzed Dehydration of Sorbitol to 1,4-Sorbitan ... forms exclusively the 3,6-anhydride and, on further reaction, 1,4:3,6-dianhydro-d-glucitol.d-Glucose and 2-acetamido-2-deoxy-d-glucose ...

  • Process for Preparing Nonionic Surfactant Sorbitan Fatty Acid ...

    The purpose of this work was to determine the course of the esterification reaction of hexitols and a long chain length fatty acid at different temperatures. Sorbitol esters of lauric acid were prepared by the esterification of sorbitol and lauric acid (molar ratio, 1:1) in the presence of p-toluenesulfonic acid as a catalyst.


    Sorbitol is fermented in good yields to sorbose by some of the members of the Acetobacter species (1, 2). Resting cells of Acetobacter suboxydans may, in the absence of a source of nitrogen, oxidize sorbitol with the con- sumption of over 4 atoms of oxygen per molecule of substrate (3, 4).

  • Preparation of Sorbitan Stearate - IIIS

    moisture separator. Sorbitol or sorbitol intramolecular condensates, fatty acids, and catalysts are fed to the reaction vessel and are mixed and stirred [7, 13]. The aim of this investigation is the preparation of sorbitan and esterification of sorbitan with stearic acid and sorbitan estearate formation. 2. Experimental 2-1. Materials

  • Method for the direct esterification of sorbitol with fatty ...

    A process for preparing a mixture of sorbitol fatty acid esters and sorbitol anhydride fatty acid esters comprising the step of: reacting a reaction mixture which is essentially free from water, comprising sorbitol and at least one free fatty acid, wherein the molar ratio of free fatty acid to sorbitol is at least 7:1, at a temperature and for ...

  • Sorbitol | C6H14O6 - PubChem

    Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.

  • acid anhydrides and water, alcohols or phenol - chemguide

    This page looks at the reactions of acid anhydrides with water, alcohols and phenols (including the manufacture of aspirin). These reactions are all considered together because their chemistry is so similar. There is also a great similarity between acid anhydrides and acyl chlorides (acid chlorides ...