responses, drug allergies, insect sting allergies and food allergies, (2) inflammatory bowel diseases, such as Crohn's disease, ulcerative colitis, ileitis and enteritis, (3) vaginitis, (4) psoriasis and inflammatory dermatoses such as dermatitis, eczema, atopic dermatitis,
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REFERENCE TO PRIOR APPLICATION. This application claims the benefit of U.S. Provisional Application No. 61/792,020, filed Mar. 15, 2013, and U.S. Provisional ...
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"Pharmaceutically acceptable acid addition salt" refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or otherwise undesirable, and which are formed with inorganic acids such as, but not limited to, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid ...
The invention provides dihydro-2H-benzo[b] [1,4]oxazine sulfonamide and related compounds, pharmaceutical compositions, methods of promoting RORγ activity, methods of increasing the amount of IL-17 in
Toxicity of many substances, their biological uptake and lipophilic storage in the body, their bioconcentrations (movements through the food chain resulting in higher concentrations), and so forth, as well as their fate in the environment can be predicted from their octanol/water partition coefﬁcients, Poct .
Due to solvent inside the microgels, they are soft objects where the term "soft" applies twofold: (i) microgels can have a soft interaction potential as it is known from other colloidal systems; (ii) the microgel itself is soft and deformable, while still retaining its structural integrity.
FIELD: medicine, pharmaceutics. SUBSTANCE: in general formulas R 1 represents substituted phenyl, substituted or unsubstituted heterocyclyl, which represents an aromatic cycloalky
Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 is 1: a C 3-8 cycloalkyl C 1-4 alkyl group, 2: a C 7-14 aralkyl group, in which the aryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of: (a) halogen, (b) C 1-4 alkyl, which is optionally substituted with 1 to 3 ...
On the basis of available 2 Cosmetic Ingredient Review Scientific Analyst/V'riter Cosmetic Ingredient Review Expert Panel Member Cosmetic Ingredient Review Director Corresponding Author: Valerie C. Robinson, Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036 Email: cirinfo©cir-safety.org 152S information, the ...
The Dictionary of Substances and their Effects Second Edition The Dictionary of Substances and their Effects Second Edition EDITOR S Gangolli, Consultant, MRC Toxicology Unit, UK EDITORIAL ADVISORY BOARD Dr D Anderson, B I B R A International, UK Dr J Chadwick, Health and Safety Executive, UK Professor L Ebdon, University of Plymouth, UK Dr D Gammon, California €PA, USA Professor L King ...
The present invention relates to the use of A1 and/or dual A1/A2b agonists of the formulae (IA) and (IB) for preparing a medicament for treating dyslipidemia, metabolic syndrome and diabetes and dyslipidemia, metabolic syndrome and diabetes in association with hypertension and cardiovascular disorders.
George Hademenos - Schaums Outline of Theory and Problems of Organic Chemistry (1999 McGraw-Hill).pdf код для вставки
A class of compounds which are (H + /K +)ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1##
The present application claims the benefit of Provisional Application U.S. No. 61/095217, filed September 8, 2008, and Provisional Application U.S. No. 61/230479, filed July 31, 2009, the complete contents of which are incorporated in this application by reference.
BACKGROUND. Field. The invention relates to biologically active compounds, compositions comprising the same, and methods of using such biologically active compounds and compositio
As the 2,4-pyrimidinediamine compounds described herein are potent inhibitors of Syk kinase, they can be used to regulate, and in particular inhibit, any signaling cascade where Syk plays a role, such as, fore example, the Fe receptor, BCR and integrin signaling cascades, as well as the cellular responses elicited through these signaling cascades.
D ow and K aw,eff vs. K ow and K° aw : Acid/base ionization effects on partitioning properties and screening commercial chemicals for long-range transport and bioaccumulation potential
Lens proporciona casi todos los documentos de patentes en el mundo como bienes públicos digitales abiertos y anotables que se integran con literatura académica y técnica junto con datos regulatorios y comerciales.
"Food-chain crops" means tobacco, crops grown for human consumption, and crops grown for feed for animals whose products are consumed by humans. "Freeboard" means the vertical distance between the top of a tank or surface impoundment dike and the surface of the waste contained therein.
The functional comonomers comprise anionic or cationic moieties (like acrylic acid or N-(3-aminopropyl) methacrylamide, respectively), giving yield to polyelectrolyte microgels with and without a pH-dependent degree of ionization (the latter can be achieved by quaternization of the amino groups).
Transcript. 1 A World Compendium The Pesticide Manual Sixteenth Edition Supplementary Entries Extended Editor: C. MacBean Promoting the science and practice of sustainable crop production
For example, a wide range of acids may be used, including but not limited to phosphoric acid, trifluoroacetic acid, p-toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, 4-bromobenzenesulfonic acid, thionyl chloride,and trimethylsilyl chloride.
namely, (1R, 2S) 1-amino-2-ethenylcyclopropylcarboxylic acid. The term "(C 1-6)alkyl" as used herein, either alone or in combination with another substituent, means acyclic, straight or branched chain alkyl substituents containing from 1 to 6 carbon atoms and includes, for example, methyl, ethyl, propyl, butyl, 1-methylethyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl and hexyl.
EPA 560/5-77-006 A STUDY OF INDUSTRIAL DATA ON CANDIDATE CHEMICALS FOR TESTING August 1977 Research Request No. 1 FINAL REPORT fice of Toxic Substances ironmental Protection Agency Washington, D.C. 20460
Novel crystalline acid addition salts forms of RPL-554 are claimed, wherein the salts, such as ethane- 1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid. .
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Nilotinib base (1 g) was suspended in water (20 ml). A solution of benzenesulfonic acid (0.4 g) in water (3ml) was added and the content was heated at 60 °C for 2-3 h. The mixture was cooled to 25-30 °C, filtered, washed with water (3 x 5 ml) and dried under vacuum for 2 h at 50-55 °C.
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