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    The nucleic acid molecule of claim 99, wherein the side chain chemistry is that of an amino acid residue selected from the group consisting of Asp, Glu, Lys, Arg, and His. 101. The nucleic acid molecule of claim 95, wherein the first amino acid residue is modified by substitution with a replacement amino acid. 102.

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    1. A population of stabilized scFv molecules, wherein the stabilized scFv molecules comprise i) a scFv linker interposed between a V H domain and a V L domain, wherein the V H and V L domains are linked by a disulfide bond between an amino acid in the V H domain and an amino acid in the V L domain, and wherein the V H and V L domains of the scFv molecules have Tm values of greater than 55° C ...

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    Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR ...

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    The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject.

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    This application is a continuation application of International Patent Application No. PCT/US2004/037929, filed Nov. 12, 2004, titled "NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO" which claims the benefit of U.S. Provisional Application Ser. No. 60/519,744, filed on Nov. 12, 2003, titled "ANTIBODIES AND VARIANTS ...

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    The invention relates to fluorescent polymers soluble in an aqueous solution carrying at least 5 fluorophores which are distributed on the polymer and which exhibit the following properties: Fluorescent Polymers Soluble in an Aqueous Solution and a Method for the Production Thereof - BIOMERIEUX S.A.

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    [0065] The term "first amino acid residue" refers to the amino acid residue (or position) of the polypeptide which is modified by the insertion, substitution, or deletion of an amino acid residue or by directly altering the side chain chemistry of the existing amino acid residue, such that the modified amino acid residue (or residue ...

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